Au(I)-Catalyzed Pictet–Spengler Reactions All around the Indole Ring

Au(I) complexes catalyze iso-Pictet–Spengler reactions. Ethylamine or methylamine chains were introduced at C2, C4, the nitrogen atom of indole ring, and corresponding substrates reacted in presence aldehydes catalytic amounts complexes, leading to a variety polycyclic scaffolds. Selectivity could be achieved course double reaction involving two successive aldehydes, highly complex molecules.